Inhibition of let-7c Regulates Cardiac Regeneration after Cryoinjury in Adult Zebrafish
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چکیده
منابع مشابه
Zebrafish fin regeneration after cryoinjury-induced tissue damage
Although fin regeneration following an amputation procedure has been well characterized, little is known about the impact of prolonged tissue damage on the execution of the regenerative programme in the zebrafish appendages. To induce histolytic processes in the caudal fin, we developed a new cryolesion model that combines the detrimental effects of freezing/thawing and ischemia. In contrast to...
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Macrophages demonstrate a high level of plasticity, with the ability to undergo dynamic transition between M1 and M2 polarized phenotypes. The role of microRNAs (miRNAs) in regulating macrophage polarization has been largely undefined. In this study, we found that miRNA let-7c is expressed at a higher level in M-BMM (M2 macrophages) than in GM-BMM (M1 macrophages). let-7c levels are also greate...
متن کاملExtensive scar formation and regression during heart regeneration after cryoinjury in zebrafish.
The zebrafish heart has the capacity to regenerate after ventricular resection. Although this regeneration model has proved useful for the elucidation of certain regeneration mechanisms, it is based on the removal of heart tissue rather than its damage. Here, we characterize the cellular response and regenerative capacity of the zebrafish heart after cryoinjury, an alternative procedure that mo...
متن کاملInduction of Myocardial Infarction in Adult Zebrafish Using Cryoinjury
The mammalian heart is incapable of significant regeneration following an acute injury such as myocardial infarction(1). By contrast, urodele amphibians and teleost fish retain a remarkable capacity for cardiac regeneration with little or no scarring throughout life(2,3). It is not known why only some non-mammalian vertebrates can recreate a complete organ from remnant tissues(4,5). To understa...
متن کاملHypoxia/Reoxygenation Cardiac Injury and Regeneration in Zebrafish Adult Heart
AIMS the adult zebrafish heart regenerates spontaneously after injury and has been used to study the mechanisms of cardiac repair. However, no zebrafish model is available that mimics ischemic injury in mammalian heart. We developed and characterized zebrafish cardiac injury induced by hypoxia/reoxygenation (H/R) and the regeneration that followed it. METHODS AND RESULTS adult zebrafish were ...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Development and Disease
سال: 2019
ISSN: 2308-3425
DOI: 10.3390/jcdd6020016